|
KMID : 0617319930030010009
|
|
Journal of Pharmacetical Sceiences Ewha Womans University
1993 Volume.3 No. 1 p.9 ~ p.18
|
|
|
Preparation and Dissolution Characteristics of Albumin Microspheres Containing Betamethasone Sodium Phosphate
|
|
|
|
|
Abstract
|
|
|
|
Albumin microspheres containing freely water soluble tetamethasone sodium phosphate(BSP) were prepared by chemical denaturation mehtod using terephthaloyl choloride(TP) as a crosslinking agent and by heat denaturation method. Their shapes, size distributions of albumin microspheres, drug contents in albumin microspheres and I vitro release profiles were studied. The shapes of albumin microspheres prepared by chemical dedaturation method were irregular and rough, whereas the shapes of albumin microspheres perpared by heat denaturation method wer spherical, smooth and compact, relatively, And the size distribution was affected by the preparing conditions, the amount of crosslingking agent or heating time of albumin microspheres. BSP powder was released completely within 2 min, whereas T_100% drug release from chemically denatured microshpheres were 420, 480 and 840 min for BSA : TP ratio of 1: 0.5, 1:1.0 and 1:1.5, respectively. And T_100% drug release from heat denatured microspheres were 10, 20 and 90 min for heating time of 30, 60 and 120min, respectively.
|
|
|
KEYWORD
|
|
|
|
|
|
FullTexts / Linksout information
|
|
|
|
|
|
Listed journal information
|
|
|
|
|